Foxp3
- 50 μL
Product Information
| Description | Foxp3 rat Monoclonal |
| Protein full name | Forkhead box protein P3 |
| Synonyms | IID, AIID, DIETER, DIETER, Forkhead box P3, Forkhead box protein P3, FOXP3delta7 |
| Immunogen | |
| Isotype | IgG |
| Purity | Affinity purification |
| Subcellular location | Nucleus |
| Uniprot ID | Q9BZS1, Q99JB6 |
Applications
| Applications | Species | Dilution | Positive Tissue |
| IHC | Mouse, Rat | 1: 50-1: 200 | kidney |
Background
Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG).
Images
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （Y2036）.
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