Anti -P53 Mouse MAb
- 50 μL
Product Information
| Description | P53 mouse monoclonal |
| Protein full name | TP53 |
| Synonyms | BCC7, LFS1, TRP53 |
| Immunogen | Recombinant human wild-type p53 protein. |
| Isotype | IgG |
| Purity | Ascites |
| Subcellular location | Cytoplasm, Nucleus |
| Uniprot ID | P04637 |
Applications
| Applications | Species | Dilution | Positive Tissue |
| IHC | Human | 1: 50-1: 400 | mammary cancer |
Background
The p53 tumor antigen is found in increased amounts in a wide variety of transformed cells. The protein is also detectable in many actively proliferating, nontransformed cells, but it is undetectable or present at low levels in resting cells. This protein induces cell cycle arrest or apoptosis in response to sublethal or severe DNA damage, respectively, by differential transcription of target genes and through transcription-independent apoptotic functions. The p53 protein contains 393 amino acids. Human p53 tumour antigen is Locatedto band 17p13. p53 mutations are common in pancreatic cancer and are absent in chronic pancreatitis.
Images
Storage
| Storage | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| Storage Buffer | Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （Y2036）.
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