产品信息

蛋白质全称	瞬时受体电位阳离子通道亚家族V6
别名	ABP/ZF, Calcium transport protein 1, CaT L, CaT like, CAT1, CATL, ECAC2, Epithelial calcium channel 2, HSA277909, LP6728
Uniprot ID	Q91WD2
免疫原	KLH偶联的小鼠TRPV6合成肽
抗体亚型	IgG
预测分子量./观测分子量.	87 kDa / 70 kDa
纯化方式	亲和纯化

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应用

应用	物种	稀释	阳性样品
WB 免疫印迹	人, 小鼠, 大鼠	1: 1000-1: 2000	结肠, 肝

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背景

Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine . Important for normal Ca(2+) ion homeostasis in the body, including bone and skin . The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism; the latter may be regulated by phosphorylation . In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner . Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating .

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图像

WB检测TRPV6蛋白(货号 YB114627). 样品: 经RIPA裂解液(货号Y2013)处理的蛋白质. 封闭: 封闭: 3%脱脂牛奶(货号YC310012)溶于TBST溶液, 室温孵育1小时. —抗: 1: 1000稀释, 4℃ 孵育过夜. 二抗: HRP标记山羊抗兔IgG (H+L) (货号YB23314), 1: 5000稀释, 室温孵育1小时.

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储存

储存条件	在-20℃下储存一年, 避免反复冻融.
储存缓冲液	含0.15% ProClin300防腐剂, 100 μg/mL牛血清白蛋白和50%甘油的磷酸盐缓冲液.

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注意:

1.本产品仅供研究使用.

2.建议用一抗稀释液(Y2036)稀释本产品.