Recombinant Anti-Androgen Receptor antibody (Rabbit mAb)
- 50 μL
Product Information
Protein full name | Androgen receptor |
Gene Id | 367 |
Immunogen | KLH conjugated Synthetic peptide corresponding to Human Androgen Receptor |
Uniprot ID | P10275 |
Source | Monoclonal, Rabbit IgG1, Kappa |
Concentration | 1mg/ml |
Purity | Recombinant Expression and Affinity purified |
Applications
IHC/IF | Human, Mouse, Rat | 1:200-1:400 | Prostate, testis |
Background
The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoform
Images
| Immunohistochemistry analysis of paraffin embedded Mouse prostate using Androgen receptor (GB14170) at dilution of 1: 20 |
| Immunohistochemistry analysis of paraffin embedded Mouse testis using Androgen receptor (GB14170) at dilution of 1: 20 |
| Immunohistochemistry analysis of paraffin embedded Rat testis using Androgen receptor (GB14170) at dilution of 1: 200 |
| Immunohistochemistry analysis of paraffin embedded Rat prostate using Androgen receptor (GB14170) at dilution of 1: 200 |
Storage
| Storage | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
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