Keap1
- 50 μL
Product Information
Description | KEAP1 Mouse polyclonal |
Protein full name | kelch-like ECH-associated protein 1 |
Synonyms | Cytosolic inhibitor of Nrf2, INrf2, KEAP1, Kelch like protein 19, KIAA0132, KLHL19 |
Immunogen | Recombinant protein corresponding to Mouse KEAP1 |
Isotype | IgA |
Purity | Affinity purification |
Subcellular location | Cytosol,Nucleoplasm,Centriolar satellite |
Predicted MW. | 70 kDa |
Observed MW. | 70 kDa |
Uniprot ID |
Applications
Applications | Species | Dilution | Positive Tissue |
WB | Human,Rat, Mouse | 1: 1000-1:4000 | 4T1, HSC-T6, NIH/3T3 |
Background
KEAP1, also named as INRF2, KIAA0132 and KLHL19, is part of a multiprotein complex that contains the CUL3-ROC1 ubiquitin ligase, which can ubiquitinate the N-terminal domain of NRF2. Two molecules of KEAP1 bind to two distinct sites in the N-terminal region of NRF2, the ETGE and DLG sites, which affect the KEAP1-NRF2 interaction and/or its physiological consequences. KEAP1 retains NFE2L2/NRF2 in the cytosol. It functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. It also retains BPTF in the cytosol.
Images
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
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