HIF-α Antibody
- 50 μL
Product Information
| Description | Hif-1α rabbit polyclonal |
| Protein full name | Hypoxia-inducible factor 1-alpha |
| Synonyms | ARNT interacting protein, ARNT-interacting protein, Basic helix loop helix PAS protein MOP1 |
| Immunogen | Synthetic peptide, corresponding to amino acids 345-398 of Human HIF-1α |
| Isotype | IgG |
| Purity | Affinity purification |
| Subcellular location | Nucleus |
| Uniprot ID | Q16665, Q61221, O35800 |
Applications
| Applications | Species | Dilution | Positive Tissue |
| IHC | Mouse, Rat | 1: 50-1: 200 | lung, brain |
Background
Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia.
Images
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
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