smad2
- 100ul
Product Information
Description | Smad2 rabbit polyclonal |
Protein full name | Mothers against decapentaplegic homolog 2 |
Synonyms | SMAD2, JV18, V18-1, MADH2, MADR2, hMAD-2, hSMAD family member 2, Mothers against DPP homolog 2, hSMAD2 |
Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse Smad2 |
Isotype | IgG |
Predicted MW. | 52 kDa |
Observed MW. | 55 kDa |
Purity | Affinity purification |
Uniprot ID | Q62432, O70436 |
Applications
applications | species | dilution | Positive tissue |
WB | Mouse, Rat | 1: 500-1: 1000 | heart, skeletal muscle |
Background
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity).
Images
| Western blot analysis of Smad2 (GB11172) at dilution of 1: 750 Lane 1: Mouse heart tissue lysate Lane 2: Mouse skeletal muscle tissue lysate Lane 3: Rat heart tissue lysate Lane 4: Rat skeletal muscle tissue lysate |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
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