Anti-NRF2 Rabbit pAb
- 50 μL
Product Information
Description | Nrf2 rabbit polyclonal |
Protein full name | Nuclear factor erythroid 2-related factor 2 |
Synonyms | NF-E2-related factor 2, NFE2-related factor 2, Nrf-2, HEBP1, NFE2L2, NRF2 |
Immunogen | E.coli-derived human Nrf2 recombinant protein (Position: Q14-D178). Human Nrf2 shares 79% and 82% amino acid (aa) sequence identity with mouse and rat Nrf2, respectively. |
Isotype | IgG |
Purity | Affinity purification |
Subcellular location | |
Predicted MW. | 68 kDa |
Observed MW. | 100 kDa |
Uniprot ID |
Applications
Applications | Species | Dilution | Positive Tissue |
WB | Human, Mouse, Rat | 1: 500-1: 2000 | Kidney, placenta, skeletal muscle, lung |
IHC | Human, Mouse, Rat | 1: 50-1: 400 | lung cancer |
Background
NRF2, also named as NFE2L2, belongs to the bZIP family and CNC subfamily. It is a transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. NRF2 is important for the coordinated up-regulation of genes in response to oxidative stress.It may be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.Nrf2 is a key player in the regulation of genes encoding for many antioxidative response enzymes.
Images
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
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