Anti-CDK4 Rabbit pAb
- 50 μL
Product Information
Description | Cdk4 rabbit polyclonal |
Protein full name | Cyclin-dependent kinase 4 |
Synonyms | Cell division protein kinase 4, PSK-J3, CDK4 |
Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1-303 of human CDK4 (NP_000066.1). |
Isotype | IgG |
Purity | Affinity purification |
Subcellular location | |
Predicted MW. | 34 kDa |
Observed MW. | 20/33 kDa |
Uniprot ID | P11802, P30285 |
Applications
Applications | Species | Dilution | Positive Tissue |
WB | Human, Mouse | 1: 500-1: 2000 | lung |
IHC | Human | 1: 50-1: 200 | colon |
IHC | Human | 1: 50-1: 200 | A549 |
Background
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.
Images
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
| 货号 | 名称 | 规格 | 价格 | 操作 |
|---|
| 货号 | 名称 | 规格 | 价格 | 操作 |
|---|