il-10
- 100 μL
Product Information
| Description | IL-10 Mouse polyclonal |
| Protein full name | IL-10 |
| Synonyms | CSIF, IL 10, IL10, IL-10, IL10A, interleukin 10, TGIF |
| Immunogen | IL-10 fusion protein Ag14870 |
| Isotype | IgG |
| Purity | Affinity purification |
| Predicted MW. | 21 kDa |
| Observed MW. | 22 kDa |
| Uniprot ID | P22301 |
Applications
| Applications | Species | Dilution | Positive Tissue |
| WB | Human, Rat | 1: 2000-1: 20000 | cell lines, including T-cells, macrophages, mast cells |
Background
Interleukin (IL)-10 is an anti-inflammatory cytokine, produced by T helper (Th) cells, macrophages, monocytes, and B cells, that plays a crucial role in preventing inflammatory and autoimmune pathologies. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-κB activity, and is involved in the regulation of the JAK-STAT signaling pathway. IL-10, along with its receptors, describes an important role in pathogenesis of various diseases, including infectious, inflammatory, autoimmune diseases. IL-10 mutations are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.
Images
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
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