ATF6
- 50 μL
Product Information
| Description | ATF6 rabbit polyclonal |
| Protein full name | Cyclic AMP-dependent transcription factor ATF-6 alpha |
| Synonyms | Activating transcription factor 6 alpha, Activating transcription factor 6, ATF 6, ATF6 alpha, ATF6, ATF6-alpha, ATF6A, ATF6A_HUMAN, cAMP dependent transcription factor ATF 6 alpha |
| Immunogen | KLH conjugated synthetic peptide derived from human ATF6 |
| Isotype | IgG |
| Purity | Affinity purification |
| Predicted MW. | 75 kDa |
| Observed MW. | 75 kDa |
| Uniprot ID | P18850 |
Applications
| Applications | Species | Dilution | Positive Tissue |
| WB | Human, Mouse, Rat | 1: 50-1: 200 | HeLa, MCF-7 |
Background
Activating transcription factor 6 (ATF6) is a transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor.During unfolded protein response an approximative 50 kDa fragment containing the cytoplasmic transcription factor domain is released by proteolysis.
Images
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
| 货号 | 名称 | 规格 | 价格 | 操作 |
|---|
| 货号 | 名称 | 规格 | 价格 | 操作 |
|---|