SIRT1
- 50 μL
Product Information
| Description | SIRT1 rabbit polyclonal |
| Protein full name | sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) |
| Synonyms | hSIR2, hSIRT1, SIR2 like protein 1, SIR2L1, SIRT1 |
| Immunogen | SIRT1 fusion protein Ag3808 |
| Isotype | IgG |
| Purity | Affinity purification |
| Predicted MW. | 82 kDa |
| Observed MW. | 110-130 kDa, 80-85 kDa |
| Uniprot ID | Q96EB6 |
Applications
| Applications | Species | Dilution | Positive Tissue |
| WB | Human, Mouse, Rat | 1:500-1: 1000 | HeLa |
Background
SIRT1, also named as SIR2L1, contains a deacetylase sirtuin-type domain and belongs to the sirtuin family. The post-translation modified SIRT1 is a 110-130 kDa protein, which contains one deacetylase sirtuin-type domain. The 75-80 kDa SirT1 fragment was detected to lack the carboxy-terminus . SIRT1 in particular initiates several signaling events relevant to cardioprotection, including: activation of endothelial nitric oxide synthase, insulin receptor signaling, and autophagy. In addition SIRT1 activation elicits resistance to oxidative stress via regulation of transcription factors and co-activators such as FOXO, Hif-2a, and NF-kB.
Images
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
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