Anti-CD86 Rabbit mAb
- 50 μL
Product Information
Description | CD86 rabbit monoclonal |
Protein full name | CD86 |
Synonyms | Activation B7-2 antigen, CD28LG2, CTLA-4 counter-receptor B7.2 2 |
Immunogen | Monoclonal antibody is produced by immunizing animals with mouse CD86 recombinant protein. |
Isotype | IgG |
Purity | Protein A purified |
Subcellular location | Membrane |
Predicted MW. | 60Da |
Observed MW. | 85 kDa |
Uniprot ID | P42082 |
Applications
Applications | Species | Dilution | Positive Tissue |
IHC | Mouse | 1: 100-1: 400 | liver, lung |
IF | Mouse | 1: 100-1: 400 | liver, lung |
Background
CD80 (B7-1, BB1) and CD86 (B7-2, B70) are members of the B7 family of cell surface ligands that regulate T cell activation and immune responses. CD80 is expressed on activated antigen presenting cells, including dendritic cells, B cells, monocytes, and macrophages. CD86 is expressed on resting monocytes, dendritic cells, activated B lymphocytes, and can be further upregulated in the presence of inflammation (1-3). CD80 and CD86 are ligands for CD28, which functions as a T cell costimulatory receptor. Interaction of CD28 with CD80 or CD86 provides the second signal required for naïve T cell activation, T cell proliferation, and acquisition of effector functions (3-7). Alternatively, CD80 and CD86 also act as ligands to CTLA-4, which results in the downregulation of T cell activity (3,7-9).
Images
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
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