pro Caspase-1 + p10 + p12
- 50 μL
Product Information
| Description | pro Caspase-1 + p10 + p12 rabbit polyclonal |
| Protein full name | caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) |
| Synonyms | CASP 1, CASP1, Caspase 1, Caspase 1/p20/p10, Caspase1, ICE, IL 1 beta converting enzyme, IL 1BC, IL1BC, IL1BCE, Interleukin 1 beta convertase, p10, p20, P45 |
| Immunogen | Recombinant protein corresponding to Mouse pro Caspase-1 + p10 + p12 |
| Isotype | IgG |
| Purity | Affinity purification |
| Predicted MW. | 45 kDa |
| Observed MW. | 45, 42, 35, 12, 10 kDa |
| Uniprot ID | P29466 |
Applications
| Applications | Species | Dilution | Positive Tissue |
| WB | Mouse, Rat, Human | 1: 1000 | RAW264.7, Raji, MCF-7, NIH/3T3, HeLa, C6, Jurkat |
Background
ASP1(caspase-1) is also named as IL1BC, IL1BCE and belongs to the peptidase C14A family. It is a cysteine protease that regulates inflammatory processes through its capacity to process and activate the interleukin-1-beta (IL1B), IL18, and IL33 precursor proteins. The active caspase-1 can increase cellular membrane permeability and intracellular calcium levels, which facilitates lysosome exocytosis and release of host antimicrobial factors and microbial products . It has 5 isoforms produced by alternative splicing. 22915-1-AP can recognize all the five isoforms of caspase 1. It also can recognize p45 procaspase and the mature fragments p10 and p20.
Images
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
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