Anti-Caspase-3 Rabbit pAb
- 100 μL
Product Information
Description | active Caspase-3 rabbit polyclonal antibody |
Protein full name | Caspase-3 |
Synonyms | Casp3, CASP3, CPP32, CPP32B, SCA-1, Caspase 3 |
Immunogen | Recombinant protein corresponding to Mouse Caspase-3 |
Isotype | IgG |
Purity | Affinity purification |
Predicted MW. | 32 kDa |
Observed MW. | 35/17/12 kDa |
Uniprot ID | P70677, Q8MJC3 |
Applications
Applications | Species | Dilution | Positive Tissue |
WB | Mouse, Rat | 1: 500-1: 1000 | liver, lung, brain |
Background
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes.
Images
 | Western blot analysis of Caspase3 (GB11767) at dilution of 1: 500 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
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