Anti-RUNX2 Rabbit pAb
- 100 μL
Product Information
| Description |
RUNX2 rabbit polyclonal |
| Protein full name |
Runt-related transcription factor 2 |
|
Synonyms |
AML3, CBF-alpha-1, CBFA1, CCD, CCD1, CLCD, OSF-2, OSF2, PEA2aA, PEBP2aA |
| Immunogen |
KLH conjugated Synthetic peptide corresponding to Mouse RUNX2 |
| Isotype | IgG |
| Purity | Affinity purification |
| Subcellular location |
Nucleus |
| Uniprot ID |
Q08775,Q9Z2J9 |
Applications
Applications | Species | Dilution | Positive Tissue |
IHC | Mouse, Rat | 1:200-1:500 | bone |
IF | Mouse, Rat | 1:200-1:500 | bone |
Background
Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. Inhibits KAT6B-dependent transcriptional activation (By similarity). In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).
Images
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Immunohistochemistry analysis of paraffin-embedded rat bone tissue using RUNX2 (GB11264) at dilution of 1:500 |
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Immunohistochemistry analysis of paraffin-embedded mouse bone using RUNX2 (GB11264) at dilution of 1:500 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
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