Anti-Von Hippel Lindau/VHL Mouse mAb
- 50 μL
Product Information
Protein full name | Von Hippel-Lindau disease tumor suppressor (Protein G7) (pVHL) |
Gene Id | 7428 |
Immunogen | Synthesized peptide derived from human pVHL |
Uniprot ID | P40337 |
Source | Mouse/IgG2b, Kappa |
Concentration | 1 mg/ml |
Purity | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
Applications
IHC/IF | Human | 1: 200-1: 500 | kindey |
Background
von Hippel-Lindau tumor suppressor(VHL) Homo sapiens Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008],
Images
|
Immunohistochemistry analysis of paraffin embedded human kindey using Von Hippel Lindau/VHL (YB14154) at dilution of 1: 200 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （Y2036）.
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