P-PTEN(Ser370)
- 50 μL
Product Information
Description | P-PTEN(Ser370) rabbit polyclonal |
Protein full name | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN |
Synonyms | PTEN, MMAC1, TEP1, BZS, DEC, CWS1, GLM2, MHAM, PTEN1, 10q23del, PTENbeta |
Immunogen | Recombinant protein corresponding to P-PTEN |
Isotype | IgG |
Purity | Affinity purification |
Subcellular location | Cytoplasm. Nucleus. Nucleus, PML body |
Predicted MW. | 47 kDa |
Observed MW. | 54 kDa |
Uniprot ID | B2R904, F2YHV0, P60484, Q6ICT7 |
Applications
Applications | Species | Dilution | Positive Tissue |
WB | Human, Mouse, Rat | 1: 500-1: 2000 | Expressed in all adult tissues, including heart, brain, placenta, lung, liver, muscle, kidney and pancreas |
Background
PTEN(Phosphatase and tensin homolog) is also named as MMAC1, TEP1 and it modulates cell cycle progression and cell survival (blockage) through down-regulating the positive cell cycle-regulator (cycle D1) by its phosphatase activity and up-regulating the negative cell cycle regulator p21 (by its lipid phosphatase activity). PTEN is an important tumor suppressor whose inactivation frequency in cancers is ranked second after p53 tumor suppressor inactivation.
Images
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （Y2036）.
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