p-creb
- 50 μL
Product Information
Description | phospho-CREB-1 rabbit polyclonal |
Protein full name | phospho-CREB-1 |
Synonyms | Active transcription factor CREB, cAMP response element binding protein, cAMP responsive element binding protein 1 |
Immunogen | KLH conjugated Synthesised phosphopeptide derived from human CREB-1 around the phosphorylation site of Ser133:YP(p-S)YR |
Isotype | IgG |
Purity | affinity purified by Protein A |
Subcellular location | Nucleus |
Predicted MW. | 37 kDa |
Observed MW. | 37 kDa |
Uniprot ID |
Applications
Applications | Species | Dilution | Positive Tissue |
WB | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep | 1:500 -1: 2000 | cerebrum, kidney, Huvec, |
Background
CREB1, also named as CREB, belongs to the bZIP family, containing one bZIP domain and one KID (kinase-inducible) domain. This protein binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. CREB stimulates transcription on binding to the CRE. This protein is stimulated by phosphorylation. Phosphorylation of both Ser-133 and Ser-142 in the SCN regulates the activity of CREB and participates in circadian rhythm generation.
Images
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （Y2036）.
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