P-EIF2α
- 50 μL
Product Information
| Description | P-EIF2α rabbit polyclonal |
| Protein full name | EIF2S1 |
| Synonyms | Eukaryotic Translation Initiation Factor 2 Subunit Alpha, Eukaryotic Translation Initiation Factor 2 Subunit 1 |
| Immunogen | Recombinant protein corresponding to Mouse P-EIF2α |
| Isotype | IgG |
| Purity | Affinity purification |
| Subcellular location | Cytoplasm, Nucleus |
| Uniprot ID | P05198 |
Applications
| Applications | Species | Dilution | Positive Tissue |
| IHC | Human, Mouse, Rat | 1: 500-1: 1000 | liver carcinoma |
Background
EIF2S1 is one subunit of the translation initiation factor EIF2, which catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the YTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with YTP by way of a reaction catalyzed by eIF-2B.
Images
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （Y2036）.
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