Anti-Phospho-GSK3 Alpha/Beta (Y279/Y216) Rabbit pAb
- 50 μL
Product Information
Description | Phospho-GSK3 Alpha /Beta (Y279/Y216) rabbit polyclonal |
Protein full name | Glycogen synthase kinase-3 alpha/beta |
Synonyms | GSK3B(Phospho-Tyr279+Tyr216), GSK3B(Phospho-Y279/Y216), p-GSK-3 Beta(Tyr279+Tyr216), p-GSK-3 beta(Y279/Y216), Glycogen synthase kinase 3 beta, GSK 3 beta, p-GSK3β, p-GSK3α, p-GSK3α/β |
Immunogen | KLH conjugated Synthetic phosphopeptide corresponding to Human GSK3 Alpha /Beta (Y279/Y216) |
Isotype | IgG |
Purity | Affinity purification |
Predicted MW. | 47/51 kDa |
Observed MW. | 47/51 kDa |
Uniprot ID |
Applications
Applications | Species | Dilution | Positive Tissue |
WB | Mouse, Rat | 1:500-1:1000 | heart, brain |
Background
Glycogen synthase kinase 3 (GSK3) is a proline directed serine threonine kinase that was initially identified as a phosphorylating and inactivating glycogen synthase, a key enzyme in glycogen metabolism. Since then, it has been shown to be involved in the regulation of a diverse array of cellular functions, including protein synthesis, cell proliferation, cell differentiation, microtubule assembly/disassembly, and apoptosis. There exists two isoforms of GSK3, alpha and beta, which are strictly regulated via phosphorylation. Phosphorylation of GSK3 beta on Ser9 (Ser21 in GSK3 alpha) is the primary mechanism responsible for growth factor inhibition of this kinase.
Images
 | Western blot analysis of GSK3 Alpha /Beta (Y279/Y216) (YB13171-1) at dilution of 1: 1000. |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （Y2036）.
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