JNK1/2/3
- 50 μL
Product Information
| Description | JNK1/2/3 rab polyclonal |
| Protein full name | Mitogen-activated protein kinase 8 |
| Synonyms | JNK 46, JNK 55, JNK, JNK1, JNK1A2, JNK2 |
| Immunogen | Synthetic peptide, corresponding to amino acids 150-200 of Human JNK1 |
| Isotype | IgG |
| Purity | Affinity purification |
| Subcellular location | Cytoplasm, Nucleus |
| Uniprot ID | P45983, P45984, P53779 |
Applications
| Applications | Species | Dilution | Positive Tissue |
| IHC | Human, Mouse, Rat | 1: 50-1: 200 | breast carcinoma, kidney carcinoma |
Background
Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. Phosphorylates the replication licensing factor CDT1, inhibiting the interaction between CDT1 and the histone H4 acetylase HBO1 to replication origins.
Images
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （Y2036）.
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