Anti-PI 3 Kinase p85 alpha Mouse mAb
- 50 μL
Product Information
| Description |
PI 3 Kinase p85 alpha mouse monoclonal |
| Protein full name |
Phosphatidylinositol 3-kinase regulatory subunit alpha |
|
Synonyms |
PIK3R1, AGM7, GRB1, IMD36, p85, p85-ALPHA, phosphoinositide-3-kinase regulatory subunit 1 |
| Immunogen |
KLH conjugated Synthetic peptide corresponding to Mouse PI 3 Kinase p85 alpha. |
| Isotype | IgG |
| Purity | Affinity purification |
|
Predicted MW. |
85 kDa |
|
Observed MW. |
80 kDa |
| Uniprot ID |
Applications
| Applications |
Species |
dilution | Positive tissue |
| WB |
Human, Mouse, Rat |
1:500-1:1000 | muscle, heart,liver |
Background
The enzyme phosphatidylinositol 3 kinase (PI3 kinase) is a lipid kinase that generates phosphatidylinositol 3, 4, 5-triphosphate in response to receptor activation in many signal transduction pathways. Class IA PI3Ks exist as a heterodimer of a catalytic 110 kDa (p110) and a regulatory p85 subunit (e.g. p85 alpha). p85 alpha is an adaptor molecule that regulates the activity of the catalytic p110 subunit by binding to phosphorylated receptor tyrosine kinases (RTKs) through its SH2 domain and mediating the interaction between p110 and the plasma membrane. p85 alpha is necessary for insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues.
Images
 |
Western blot analysis of PI 3 Kinase p85 alpha (YB13172-1) at dilution of 1:1000. Lane 1: Hela cell lysate Lane 2: HepG2 cell lysate Lane 3: Jurkat cell lysate Lane 4: Mouse muscle tissue lysate Lane 5: Mouse heart tissue lysate Lane 6: Mouse liver tissue lysate Lane 7: Rat muscle tissue lysate Lane 8: Rat heart tissue lysate Lane 9: Rat liver tissue lysate |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （Y2036）.
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