Gene Name Synonym

IL21R, CD360, NILR

Species

Human

Accession

Q9HBE5

Source

HEK293 cells

SPECIFICATIONS

Amino acid sequence

Cys20-Glu232 is expressed with a 10×His tag at the C terminus

Molecular Weight

28.5 kDa

Purity

>95.0% as determined by SDS-PAGE

Endotoxin

<5 EU mg^-1

Formulation

Lyophilized from sterile PBS, pH 7.4.Normally 5%-8% trehalose and mannitol are added as protectants before lyophilization.

Reconstitution

Dissolved in sterile water, it is recommended to add 0.1% HSA or BSA for long-term preservation.

STORAGE

Stability and Storage

12 months from date of receipt at -20°C to -70°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for almost 6 months (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

BACKGROUND

Interleukin-21 receptor (IL21R) is also known as CD antigen CD360, Novel interleukin receptor (NILR), is a receptor for interleukin-21 and belongs to the type I cytokine receptor family or type 4 subfamily. IL21R contains two fibronectin type-III domains. IL21R is selectively expressed in lymphoid tissues and most highly expressed in thymus and spleen. IL21R transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. CD360 is discovered as a novel member of the class-I-cytokine-receptor family and is selectively expressed in lymphoid tissues. The CD360 is widely distributed on lymphohematopoietic cells and IL21 impacts some cell types, including CD8+ memory T cells, NK cells, and subsets of CD4 memory T cells.

Data

SDS-PAGE

Bioactivity

Testing in progress.

Recombinant Human CD360 Protein was determined by SDS-PAGE with Coomassie Blue.