p21
- 50 μL
Product Information
Description | P21 rabbit polyclonal |
Protein full name | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
Synonyms | CAP20, CDK interacting protein 1, CDKN1, CDKN1A, CIP1, MDA 6, MDA6, P21, p21CIP1, PIC1, SDI1, WAF1 |
Immunogen | |
Isotype | IgG |
Purity | Antigen affinity purification |
Subcellular location | Secreted |
Predicted MW. | 21 kDa |
Observed MW. | 21 kDa |
Uniprot ID |
Applications
Applications | Species | Dilution | Positive Tissue |
WB | 1:500 -1:1000 | HeLa, MCF-7, HUVEC, HEK-293, HEK-293T | |
IP : | 0.5-4.0 ug for IP and 1:500-1:2000 for WB | MCF-7 |
Background
CDKN1A (p21, CIP1, WAF1) is a cyclin-dependent kinase inhibitor. CDKN1A binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at the G1 phase. The expression of CDKN1A is induced by wild-type but not mutant p53 protein, through which CDKN1A mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli.
Images
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （Y2036）.
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