cyclinD1
- 50 μL
Product Information
| Description | CyclinD1 Rabbit monoclonal |
| Protein full name | G1/S-specific cyclin-D1 |
| Synonyms | B cell lymphoma 1 protein, CCND1, cyclin D1, D11S287E, G1/S specific cyclin D1, PRAD1, PRAD1 oncogene, U21B31 |
| Immunogen | Synthetic peptide within Human Cyclin D1 (C terminal). The exact sequence is proprietary |
| Isotype | IgG |
| Purity | Affinity purification |
| Subcellular location | Nucleus |
| Uniprot ID | P24385, P25322, P39948 |
Applications
| Applications | Species | Dilution | Positive Tissue |
| IHC | Human, Mouse, Rat | 1: 100-1: 500 | kidney carcinoma, hepatocellular carcinoma |
Background
Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (YB) protein family including YB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of YB1 allows dissociation of the transcription factor E2F from the YB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates YB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner
Images
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （Y2036）.
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